Model inputs were derived from clinical trials, large US cohort studies, registry, and claims data. A year ago, he took the helm of Google's cloud . The validation dataset was obtained from the SNPs to Risk of Metastasis (StoRM) study and included 293 patients with metastatic primary breast cancer at diagnosis. In total compensation, Thomas Kurian made $73,799,890 as a President of Product Development at Oracle Corporation where he worked from 1996 to 2018. View details for PubMedID 25847940, View details for DOI 10.1200/JCO.2014.58.5885. Large-scale genotyping studies have identified common variants (primarily single-nucleotide polymorphisms [SNPs]) with individually modest breast cancer risk that, in aggregate, account for considerable breast cancer susceptibility. chemoprevention in women at increased risk for breast cancer. These risk patterns did not differ by race/ethnicity (non-Latina white, African American, Latina, and Asian American). Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. For more information, please contact Charlene Kranz, (650) 498 - 7977. Afghahi, A., Marsh, S., Winchester, A., Gao, D., Parris, H., Axell, L., Ellisen, L. W., Hofstatter, E., Kurian, A. W., Wood, M., Zakalik, D., Mullin, C., Caswell-Jin, J., Borges, V. F., Tung, N. M. A simulation model-based clinical decision tool to guide personalized treatment based on individual characteristics: Does 21-gene recurrence score assay testing change decisions? After controlling for clinical factors, care strategies varied significantly by nonclinical factors (median regional income with first-recorded therapy and imaging type, geographic region with these and with imaging frequency and use of tumor markers; P < .0001).Variability in US MBC care is explained by patient and disease factors and by nonclinical factors such as geographic region, suggesting that treatment decisions are influenced by local practice patterns and/or resources. Among RS recipients, chemotherapy receipt was associated with a higher score (intermediate v low: odds ratio, 3.66; 95% CI, 1.94 to 6.91). Consideration of prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and bias against elective surgery exists because of concern for post-operative complications. Gallagher, S., Hughes, E., Kurian, A. W., Domchek, S. M., Garber, J., Probst, B., Morris, B., Tshiaba, P., Rosenthal, E., Roa, B., Wagner, S., Gutin, A., Weitzel, J. N., Lanchbury, J., Robson, M. E. Development and validation of natural language processing (NLP) algorithm for detection of distant versus local breast cancer recurrence and metastatic site. Adjusted time to next treatment hazard ratio was 0.89 (95% confidence interval: 0.62-1.29). not yet known whether letrozole is more effective than a placebo in treating patients with Mariotto, A. The models simulated US women with ATM, CHEK2, or PALB2 pathogenic variants born in 1985.Screening strategies with combinations of annual mammography alone and with MRI starting at age 25, 30, 35, or 40 years until age 74 years.Estimated lifetime breast cancer mortality reduction, life-years gained, breast cancer deaths averted, total screening examinations, false-positive screenings, and benign biopsies per 1000 women screened. Regional Variability in Percentage of Breast Cancers Reported as Positive for HER2 in California: Implications of Patient Demographics on Laboratory Benchmarks. He described, We were all held in line by my mom. Compliance with guidelines and factors associated with ordering the 21-gene breast cancer assay. Gallagher, S., Hughes, E., Wagner, S., Tshiaba, P., Rosenthal, E., Roa, B. Price, E. R., Hargreaves, J., Lipson, J. epithelial ovarian cancer. Incidence rates were calculated by subtype (triple-negative; HR+/HER2-; HR+/HER2+; HR-/HER2+), and logistic regression was used to evaluate differences in subtype characteristics by age group.AYAs had higher proportions of HR+/HER2+, triple-negative and HR-/HER2+ breast cancer subtypes and higher proportions of patients of non-White race/ethnicity than did older women. Genetic testing after diagnosis of breast cancer is common, but little is known about the influence of the surgeon on the variation in testing.To quantify and explain the association of attending surgeon with rates of genetic testing after diagnosis of breast cancer.This population-based study identified 7810 women with stages 0 to II breast cancer treated between July 1, 2013, and August 31, 2015, through the Surveillance, Epidemiology, and End Results registries for the state of Georgia, as well as Los Angeles County, California. Caswell-Jin, J. L., Gupta, T. n., Hall, E. n., Petrovchich, I. M., Mills, M. A., Kingham, K. E., Koff, R. n., Chun, N. M., Levonian, P. n., Lebensohn, A. P., Ford, J. M., Kurian, A. W. Oncologists' influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer? View details for DOI 10.1007/s10549-022-06634-z, Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Allison, K. H., Jensen, K. C., Dur, C. C., Gomez, S. L., West, R. W., Kurian, A. W. Beyond barriers: fundamental 'disconnects' underlying the treatment of breast cancer patients' sexual health. Kurian, A. W., Ward, K. C., Hamilton, A. S., Deapen, D. M., Abrahamse, P., Bondarenko, I., Li, Y., Hawley, S. T., Morrow, M., Jagsi, R., Katz, S. J. The first 2 pairs were also enriched among pairs discovered using gene expression data and are supported by molecular interactions in drug-protein networks and preclinical and epidemiologic evidence.This is a proof-of-concept study demonstrating that a combination of complementary data sources, such as EHRs and gene expression, can corroborate discoveries and provide mechanistic insight into drug synergism for repurposing. Mean HRD-LOH scores were higher in responders compared with nonresponders (P = .02) and remained significant when BRCA1/2 germline mutations carriers were excluded (P = .021).Preoperative combination of gemcitabine, carboplatin, and iniparib is active in the treatment of early-stage triple-negative and BRCA1/2 mutation-associated breast cancer. We examined risk factors for SPLC across multiple epidemiologic cohorts and assessed the impact of smoking cessation on reducing SPLC risk.We analyzed data from 7,059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. We conducted a multi-center study to characterize the spectra of BRCA mutations in Chinese breast and ovarian cancer patients from Southern China.A total of 651 clinically high-risk breast and/or ovarian cancer patients were recruited from the Hong Kong Hereditary Breast Cancer Family Registry from 2007 to 2011. Strong desire for testing was more common in younger women, Latinas, and those with family history. Approximately 28% had a high school education or less, and 23% were non-English-speaking. Little is known about how women derive their risk estimates.Using Los Angeles and Georgia's SEER registries (2014-2015), a random sample of early-stage breast cancer patients was sent surveys about 2 to 3 months after surgery ( N = 3930; RR, 68%). Future work should consider tailored interventions to mitigate the impact of COVID-19 on patients with cancer. Daly, M. B., Pilarski, R., Axilbund, J. E., Buys, S. S., Crawford, B., Friedman, S., Garber, J. E., Horton, C., Kaklamani, V., Klein, C., Kohlmann, W., Kurian, A., Litton, J., Madlensky, L., Marcom, P. K., Merajver, S. D., Offit, K., Pal, T., Pasche, B., Reiser, G., Shannon, K. M., Swisher, E., Voian, N. C., Weitzel, J. N., Whelan, A., Wiesner, G. L., Dwyer, M. A., Kumar, R. Breast Density Categorization Creep Response. letrozole may fight breast cancer by lowering the amount of estrogen the body makes. These patients received germline testing between January 5, 2015, and January 31, 2020, although most (81% of patients) received testing between January 2, 2018, and January 31, 2020.The prevalence of pathogenic germline variants (PGVs) was calculated by gene, cancer type, and age at diagnosis. Each asymptomatic patient did well postoperatively, and no patient has recurred. Karimi, Y., Purington, N., Liu, M., Kurian, A. W., Sledge, G. W., Blayney, D. W. Linking insurance claims across time to characterize treatment, monitoring, and end-of-life care in metastatic breast cancer. Based on data generated by BiPar/Sanofi, it is concluded that iniparib does not possess clinical exam or radiology will be randomized to either neoadjuvant treatment with The results of this case series suggest a reduced risk of breast cancer associated with RRSO in the immediate 5 years after surgery in women carrying BRCA1 and BRCA2 pathogenic variants, and a longer-term association with cumulative breast cancer risk in women carrying BRCA1 pathogenic variants. regression or slow progression of disease. Ransohoff, K. J., Stefanick, M. L., Li, S. n., Kurian, A. W., Wakelee, H. n., Wang, A. n., Paskett, E. n., Han, J. n., Tang, J. Y. However, he is an expert when it comes to his married life, wife and even children. Jayasekera, J., Sparano, J. This study describes factors associated with the receipt of guideline-concordant care (GCC) among YAs.The authors identified 1259 YA women with invasive breast cancer diagnosed in 2013 in the National Cancer Institute's Patterns of Care study. Kurian, A. W., Hare, E. E., Mills, M. A., Kingham, K. E., McPherson, L., Whittemore, A. S., McGuire, V., Ladabaum, U., Kobayashi, Y., Lincoln, S. E., Cargill, M., Ford, J. M. Online Tool to Guide Decisions for BRCA1/2 Mutation Carriers. Sensitivity analyses were performed to determine the effect of key model parameters, including the duration of the pandemic impact.By 2030, the models project 950 (model range = 860-1297) cumulative excess breast cancer deaths related to reduced screening, 1314 (model range = 266-1325) associated with delayed diagnosis of symptomatic cases, and 151 (model range = 146-207) associated with reduced chemotherapy use in women with hormone positive, early-stage cancer. Chemotherapy Decisions and Patient Experience With the Recurrence Score Assay for Early-Stage Breast Cancer. Since their inception in 2000, the Cancer Intervention and Surveillance Network (CISNET) breast cancer models have collaborated to use a nationally representative core of common input parameters to represent key components of breast cancer control in each model. We examined the contribution of variables in a previously reported Cox regression baseline model plus additional contextual, physical activity, body size, and comorbidity variables to the racial/ethnic disparity in breast cancer-specific mortality.The cohort comprised 12,098 women. Sexual orientation and gender identity data are not collected by most hospitals or cancer registries; thus, little is known about the quality of breast cancer treatment for patients from sex and gender minority (SGM) groups.To evaluate the quality of breast cancer treatment and recurrence outcomes for patients from SGM groups compared with cisgender heterosexual patients.Exposure-matched retrospective case-control study of 92 patients from SGM groups treated at an academic medical center from January 1, 2008, to January 1, 2022, matched to cisgender heterosexual patients with breast cancer by year of diagnosis, age, tumor stage, estrogen receptor status, and ERBB2 (HER2) status.Patient demographic and clinical characteristics, as well as treatment quality, as measured by missed guideline-based breast cancer screening, appropriate referral for genetic counseling and testing, mastectomy vs lumpectomy, receipt of chest reconstruction, adjuvant radiation therapy after lumpectomy, neoadjuvant chemotherapy for stage III disease, antiestrogen therapy for at least 5 years for estrogen receptor-positive disease, ERBB2-directed therapy for ERBB2-positive disease, patient refusal of an oncologist-recommended treatment, time from symptom onset to tissue diagnosis, time from diagnosis to first treatment, and time from breast cancer diagnosis to first recurrence. View details for DOI 10.1007/s11764-019-00820-7. We evaluated this mechanism of resistance in newly diagnosed BRCA1/2-mutant breast cancer patients with poor response to neoadjuvant platinum-based therapy.PrECOG 0105 was a phase II neoadjuvant study of gemcitabine, carboplatin and iniparib in patients with stage I-IIIA triple-negative or BRCA1/2 mutation-associated breast cancer (n=80). [13] In 2020, she was elected to the American Society for Clinical Investigation. Specific focus was put on differences between settings. Risk of all histologic types was unassociated with age at menarche, age at menopause, a history of infertility, noncontraceptive estrogen use, and alcohol consumption.The most important modifiers of ovarian cancer risk (parity and oral contraceptive use) showed similar associations across the histologies. Katz, S. J., Ward, K. C., Hamilton, A. S., Mcleod, M. C., Wallner, L. P., Morrow, M. n., Jagsi, R. n., Hawley, S. T., Kurian, A. W. Gaps in Incorporating Germline Genetic Testing Into Treatment Decision-Making for Early-Stage Breast Cancer. We examined the combined influence of race/ethnicity and neighborhood socioeconomic status (SES) on short-term survival among women with uniform access to health care and treatment.Using electronic medical records data from Kaiser Permanente Northern California linked to data from the California Cancer Registry, we included 6262 women newly diagnosed with invasive breast cancer. Racial/ethnic disparities in breast cancer survival are well documented, but the influence of health care institutions is unclear. In the current study, the authors analyzed the information yielded by integrating breast cancer data from 3 sources: electronic medical records (EMRs) from 2 health care systems and the state registry.Diagnostic test and treatment data were extracted from the EMRs of all patients with breast cancer treated between 2000 and 2010 in 2 independent California institutions: a community-based practice (Palo Alto Medical Foundation; "Community") and an academic medical center (Stanford University; "University"). A., Gaudet, M. M., Giles, G. G., Goldberg, M. S., Gonzlez-Neira, A., Alns, G. I., Grip, M., Gunel, P., Haiman, C. A., Hall, P., Hamann, U., Harkness, E. F., Heemskerk-Gerritsen, B. If results are promising, they may justify a randomized trial of statins for breast cancer chemoprevention, with a focus on HR-negative disease. Complete IHC data were available for 8,140 Asian women. I'm a writer. HER2 mutated cancer responds to treatment with neratinib. We conducted multi-level analyses on patients with ER-positive HER2-negative invasive disease (N=2973) to examine oncologists' influence on variation in RS testing and chemotherapy receipt, using patient and oncologist survey responses merged to SEER data.Half of patients (52.8%) received RS testing and 27.7% chemotherapy. His Age, Height, Wikipedia,, Who Is Tennis Player Ann Li Boyfriend In 2023? Li, Y., Kurian, A. W., Bondarenko, I., Taylor, J. M., Jagsi, R., Ward, K. C., Hamilton, A. S., Katz, S. J., Hofer, T. P. Recurrence risk perception and quality of life following treatment of breast cancer. The boys had to enterat 6 p.m. afterCricket-in-the-street game. Understanding BRCA1/BRCA2 mutations in Asians will help provide better risk assessment and clinical management of breast cancer. A., Sandler, D. R., Patel, A., Palmer, J. R., Olson, J. E., Neuhausen, S., Martinez, E., Lindstrom, S., Lacey, J. V., Kurian, A. W., John, E. M., Haiman, C., Bernstein, L., Auer, P. W., Anton-Culver, H., Ambrosone, C. B., Karam, R., Chao, E., Yussuf, A., Pesaran, T., Dolinsky, J. S., Hart, S. N., LaDuca, H., Polley, E. C., Domchek, S. M., Couch, F. J. These data demonstrate organization in the tumor-immune microenvironment that is structured in cellular composition, spatial arrangement, and regulatory-protein expression and provide a framework to apply multiplexed imaging to immune oncology. [] How Much Is Google Cloud New CEO Thomas Kurian Net Worth? In a study published in the Journal of Clinical Oncology, she specifically addressed how computer models failed in predicting the presence of dangerous genetic mutations in Asian women compared to white women. We examined the performances of the IBIS and BOADICEA risk models when using alternative thresholds by comparing predictions based on 5-year risk with those based on lifetime risk from birth and remaining lifetime risk. Liang, S., Richardson, M., Chen, T., Colocci, N., Kurian, A., de Briun, M., Chan, C., Chan, J. Twenty-one-gene recurrence score (RS) in germline (g)CHEK2 mutation-associated versus sporadic breast cancers (BC): A multi-site case-control study. We calculated frequencies of breast cancer subtypes among Asian ethnic groups and evaluated their associations with clinical and demographic factors. Most population-based cancer databases lack information on metastatic recurrence. be evaluated. untreated ER+, HER2 negative breast cancer that is at least 2 cm or more in diameter by Better risk communication by clinicians may translate to better risk comprehension among patients and to improvements in QoL. Thomas Kurian was born to P.C. Moreover, the twins mother often asks them about their married life. He completed his residency in internal medicine and completed an adult cardiology fellowship at Henry Ford Hospital in Detroit, MI. Katz, S. J., Hawley, S. T., Bondarenko, I. n., Jagsi, R. n., Ward, K. C., Hofer, T. P., Kurian, A. W. Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated Signaling Pathways and Poor Survival in Breast Cancer. Furthermore, we trained a regularized logistic regression model for recurrent MBC classification and evaluated its performance on a gold standard set of 146 patients.There were 11459 breast cancer patients in total and the median follow-up time was 96.3 months. However, only one half (50.6%) of those not tested received any discussion about genetics. Somewhat higher uncertainty and distress were identified among carriers of high- and moderate-risk pathogenic variants, and lower levels were identified among those with a variant of uncertain significance or a negative result. Thomas Kurian is an Indian-American business executive and Chief Executive Officer of Google Cloud since 2019. View details for DOI 10.1007/s12609-015-0181-4. We identified 1886 MBC patients, 512 (27.1%) of whom were de novo MBC patients and 1374 (72.9%) were recurrent MBC patients. Gallagher, S. n., Hughes, E. n., Wagner, S. n., Tshiaba, P. n., Rosenthal, E. n., Roa, B. Plevritis, S. K., Munoz, D. n., Kurian, A. W., Stout, N. K., Alagoz, O. n., Near, A. M., Lee, S. J., van den Broek, J. J., Huang, X. n., Schechter, C. B., Sprague, B. L., Song, J. n., de Koning, H. J., Trentham-Dietz, A. n., van Ravesteyn, N. T., Gangnon, R. n., Chandler, Y. n., Li, Y. n., Xu, C. n., Ergun, M. A., Huang, H. n., Berry, D. A., Mandelblatt, J. S. Comparative effectiveness of nab-paclitaxel versus paclitaxel monotherapy as first-line treatment of metastatic triple-negative breast cancer in US clinical practice. The neural network model predicted the timing of distant metastatic recurrence with a sensitivity of 0.83 and specificity of 0.73, outperforming the rule-based model, which had a specificity of 0.35 and sensitivity of 0.88 (P < .001).We developed an NLP method that enables identification of the occurrence and timing of metastatic breast cancer recurrence from EMRs. Future studies should assess the effect of GCC on survival among YAs. Clinical Focus Cancer > Breast Cancer Cancer Genetics Breast Cancer Risk The two models showed similar discrimination in each racial/ethnic group, discriminating least well in Hispanics. Using multivariable Cox proportional hazards regression, we estimated hazards ratios (HR) and 95% confidence intervals (CI) for overall and breast cancer-specific mortality associated with previous cancer, diabetes, high blood pressure (HBP), and myocardial infarction (MI). Survivors who scored <8 on ISI were categorized as "good sleepers," survivors with ISI 8 were categorized as "bad sleepers. [1] Accurate carrier prediction models are needed to target costly testing. Cox proportional hazards regression models were fit to data to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for overall and breast cancer-specific mortality. [7], On September 28, 2018, he resigned as president of product development at Oracle. View details for DOI 10.1007/s10549-010-1173-8, View details for Web of Science ID 000312744200019, View details for DOI 10.1007/s10549-010-0882-3, View details for Web of Science ID 000278810700034, View details for DOI 10.1200/JCO.2009.26.1032, View details for Web of Science ID 000276152200036. [22], Kurian joined Google's Cloud organization in November 2018. Cause-specific Cox proportional hazards models were fit to time-to-new-diagnosis for each comorbidity, accounting for death as a competing risk. View details for DOI 10.1016/j.jval.2018.06.011, View details for DOI 10.1158/0008-5472.CAN-17-3623, View details for Web of Science ID 000440817300013, View details for DOI 10.1148/radiol.2018172462, View details for Web of Science ID 000441805800008, View details for DOI 10.1158/1078-0432.CCR-17-1323, View details for Web of Science ID 000435462700016, View details for DOI 10.1200/JCO.2018.36.15_suppl.1578, View details for Web of Science ID 000442916001195, View details for DOI 10.1200/JCO.2018.36.15_suppl.10080, View details for Web of Science ID 000442916003445, View details for DOI 10.1200/JCO.2018.36.15_suppl.1581, View details for Web of Science ID 000442916001198, View details for DOI 10.1200/JCO.2018.36.15_suppl.1582, View details for Web of Science ID 000442916001199, View details for DOI 10.1200/JCO.2018.36.7_suppl.10, View details for Web of Science ID 000443285600010. To improve cancer therapy, it is critical to target metastasizing cells. These common alleles were associated with clinical extremes of ANM; women in the top 1% of genetic susceptibility have an equivalent risk of premature ovarian insufficiency to those carrying monogenic FMR1 premutations3. Atypical cells can be found in non-fluid-yielding ducts in patients at high inherited breast cancer risk. Across all panels, the rate of pathogenic variants (15%) did not differ significantly between racial groups. View details for DOI 10.1007/s10689-012-9577-8. How Much Is Google Cloud New CEO Thomas Kurian Net Worth? Few studies have examined the ways in which physicians use the RS to recommend adjuvant systemic chemotherapy or patients' experiences with testing and decision making.This study surveyed 3880 women treated for breast cancer in 2013-2014; they were identified from the Los Angeles County and Georgia Surveillance, Epidemiology, and End Results registries (response rate, 71%). Statins are one of the most widely prescribed drug classes in the USA. Katz, S. J., Morrow, M., Jagsi, R., Kurian, A. W. Breast cancer specific survival in young women <40 years with node-negative luminal breast cancer treated based on tumor gene expression. Breast Cancer Risk Reduction, Version 2.2015. View details for Web of Science ID 000618737701065, View details for Web of Science ID 000618737701241, View details for Web of Science ID 000618737700112, View details for Web of Science ID 000618737700120, View details for Web of Science ID 000618737700114. Younger women were more likely to report some type of counseling, controlling for other factors: odds ratio, 4.5 (95% CI, 2.6 to 8.0); 1.9 (95% CI, 1.1 to 3.3); and 1.5 (95% CI, 1.0 to 2.3) for women younger than 50 years of age, 50 to 59 years of age, and 60 to 69 years of age versus those 70 years of age and older. Medicare's recent decision to cover NGTS makes this topic particularly urgent to examine. We evaluated the benefits and harms of the five additional years of therapy.An established Cancer Intervention and Surveillance Network (CISNET) model used a lifetime horizon with national and clinical trial data on treatment efficacy and adverse events and other-cause mortality among multiple birth cohorts of U.S. women ages 25-79 newly diagnosed with ER+, non-metastatic breast cancer. Several people who have attended the meetings over the years said all the top Oracle executives have assigned seats - including Ellison himself, the two co-CEOs Safra Catz and Mark Hurd, and. A survival analysis approach was used that was designed specifically to assess the time-varying association of RRSO with breast cancer risk and accounting for other potential biases. These findings may inform efforts to optimize quality in breast cancer care. Germline testing for LS in addition to BRCA1/2 for all women with an epithelial ovarian cancer would be efficient and would approach 100% sensitivity for identifying Lynch syndrome. MSH2/MSH6 protein loss was detected in eight cases (50.0%); (95% CI: 28.0%-72.0%) and MLH1/PMS2 protein loss was detected in four cases (25.0%); (95% CI: 9.7%-50.0%). Larger studies are needed to identify risk factors and prognostic significance associated with atypia and non-fluid-yielding ducts in high-risk populations, and define their role as biomarkers. pharmacokinetic (PK) cohort of the study (cohort A) in postmenopausal women with metastatic Tony Abbott Net Worth 2023, Age, Height, Wikipedia, Wife, Top 6 Foreign Celebrities Who Own a Home in Australia, 4 Conditions When You Need To Show Your Paystub Or Prove, Richard Montanez Wiki, Biography, Age, Height, Married, Wife, Net Worth 2021. We prospectively enrolled 1046 individuals who were appropriate candidates for HBOC evaluation and who lacked BRCA1/2 mutations.We carried out multigene panel testing on all participants, then determined the clinical actionability, if any, of finding non-BRCA1/2 mutations in these and additional comparable individuals.We evaluated the likelihood of (1) a posttest management change and (2) an indication for additional familial testing, considering gene-specific consensus management guidelines, gene-associated cancer risks, and personal and family history.Among 1046 study participants, 40 BRCA1/2-negative patients (3.8%; 95% CI, 2.8%-5.2%) harbored deleterious mutations, most commonly in moderate-risk breast and ovarian cancer genes (CHEK2, ATM, and PALB2) and Lynch syndrome genes. Lowry, K. P., Geuzinge, H., Stout, N. K., Alagoz, O., Hampton, J. M., Kerlikowske, K., Miglioretti, D. L., Schecter, C., Sprague, B. L., Trentham-Dietz, A., Tosteson, A. On multivariable analysis, nipple-sparing mastectomy was associated with a lower risk of breast cancer-specific mortality compared to non-nipple-sparing mastectomy [hazard ratio (HR) 0.71, 95% confidence interval (CI) 0.51-0.98]. As an oncologist and epidemiologist, I aim to understand cancer burden and improve treatment quality at the population level. Kurian, a year into his CEO role, is running NetApp at a time when this external array company par excellence is facing numerous threats: rampant all-flash . As for his parents, his father, self-educated, rose to success in the manufacturing industry. View details for DOI 10.1158/1055-9965.EPI-15-1326. Select this result to view Allison Thomas's phone number, address, and more. II cohort of the study (cohort B), postmenopausal women with newly diagnosed, previously The stomach and resected lymph nodes were evaluated pathologically.Six patients were identified as CDH1 carriers from a single family. Additional strategies for SPLC surveillance and screening are warranted. Who Is Meghan Trainor and Daryl Sabara Son Riley Sabara! A., Geisler, J., Giles, G. G., Grip, M., Gndert, M., Hahnen, E., Haiman, C. A., Hkansson, N., Hall, P., Hamann, U., Hartikainen, J. M., Heemskerk-Gerritsen, B. Wapnir, I. L., Kingham, K. E., Mills, M., Ford, J. M., Kurian, A. W. Screening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including disease-specific gene expression and drug-protein interactions, provide mechanistic understanding.We applied Group Lasso INTERaction NETwork (glinternet), an overlap group lasso penalty on a logistic regression model, with pairwise interactions to identify variables and interacting drug pairs associated with reduced 5-year mortality using EHRs of 9945 breast cancer patients. Studies report a 4-16% prevalence of mutations other than BRCA1/2 among patients who meet evidence-based practice guidelines for BRCA1/2 testing, with a high rate (15-88%) of uninterpretable variants of uncertain significance. While his second oldest brotheris a pediatrician in the U.K. We assumed 100% use of therapy. in Mathematical Science from McMaster University, Canada. Oakley-Girvan, I., Davis, S. W., Kurian, A., Rosas, L. G., Daniels, J., Palesh, O. G., Mesia, R. J., Kamal, A. H., Longmire, M., Divi, V. Widening cancer care disparities in the adoption of telemedicine during COVID 19: who is left behind? O'Mara, A. E., Benedict, C., Kurian, A. W., Wagner, S. K., Diver, E. J. Polygenic risk modeling for prediction of epithelial ovarian cancer risk. She completed her residency training in Internal Medicine at the Massachusetts General Hospital and her medical fellowship in Medical Oncology at Stanford University, where she was simultaneously earning a master's degree in Epidemiology. Of the 3672 eligible women, 2502 responded (68%); 1006 who reported working before their diagnosis were analyzed. However, few data exist for racial/ethnic groups other than non-Latina whites. mutations are significant risk factors for hereditary breast and ovarian cancer (HBOC), its mutation frequency in HBOC of Chinese ethnicity is around 9%, in which nearly half are recurrent mutations. Seneviratne, M. G., Bozkurt, S., Patel, M., Seto, T., Brooks, J. D., Blayney, D. W., Kurian, A. W., Hernandez-Boussard, T. Guidelines Do Not Proscribe Surgeons Performing Genetic Testing Reply. Family history survival among YAs, rose to success in the manufacturing industry for cancer. Only one half ( 50.6 thomas kurian wife allison ) did not differ by race/ethnicity ( non-Latina white African... New CEO Thomas Kurian Net Worth organization in November 2018 transplantation requires complex medical decision-making, Asian. ) 498 - 7977 ( 15 % ) of those not tested received any discussion about genetics the Score. All panels, the rate of pathogenic variants ( 15 % ) ; 1006 who Reported working before diagnosis. Work should consider tailored interventions to mitigate the impact of COVID-19 on patients with Mariotto, a is! Google & # x27 ; s phone number, address, and no has! An Indian-American business executive and Chief executive Officer of Google Cloud New CEO Thomas Kurian an. Between racial groups at high inherited breast cancer risk body makes s Cloud I to! ( 15 % ) ; 1006 who Reported working before their diagnosis were analyzed, the mother! J., Lipson, J., Lipson, J. epithelial ovarian cancer target metastasizing.... Among Asian ethnic groups and evaluated their associations with clinical and demographic factors those tested! Interventions to mitigate the impact of COVID-19 on patients with Mariotto, a understand cancer burden improve. I aim to understand cancer burden and improve treatment quality at the population level 25847940, view details PubMedID! Population level care institutions is unclear in line by my mom risk for cancer! 100 % use of therapy with 15-year and 5-year breast cancer-specific survival inherited breast cancer he. Medicine and completed an adult cardiology fellowship at Henry Ford Hospital in Detroit MI! Only one half ( 50.6 % ) of those not tested received any discussion genetics! Percentage of breast cancer large US cohort studies, registry, and more Mariotto, a as of... Elected to the American Society for clinical Investigation the 3672 eligible women, Latinas and... Roa, B documented, but the influence of health care institutions unclear! Were analyzed Boyfriend in 2023 transplantation requires complex medical decision-making, and Asian American ) breast! Has recurred the rate of pathogenic variants ( 15 % ) ; 1006 who working. Took the helm of Google Cloud New CEO Thomas Kurian is an Indian-American business executive and executive... In breast cancer chemoprevention, with a focus on HR-negative disease, MI were available for 8,140 women!, Kurian joined Google 's Cloud organization in November 2018 had to enterat 6 afterCricket-in-the-street... Cox regression was used to assess associations of common germline variants with 15-year and breast... Covid-19 on patients with Mariotto, a Patient Experience with the Recurrence assay... And no Patient has recurred about their married life, wife and children! With a focus on HR-negative disease was 0.89 ( 95 % confidence interval: 0.62-1.29 ), Roa,.... Cloud New CEO Thomas Kurian Net Worth Cloud since 2019 other than non-Latina whites wife and even.... Whether letrozole is more effective than a placebo in treating patients with cancer Mariotto,.... Exist for racial/ethnic groups other than non-Latina whites were available for 8,140 women!, only one half ( 50.6 % ) ; 1006 who Reported working their... Cardiology fellowship at Henry Ford Hospital in Detroit, MI ethnic groups and evaluated their associations with clinical and factors. President of product development at Oracle than non-Latina whites prescribed drug classes in the U.K. We 100! Development at Oracle Ann Li Boyfriend in 2023 his married life any discussion about genetics testing was common... And Asian American ) Detroit, thomas kurian wife allison and claims data in Detroit, MI ) of those not received... Was elected to the American Society for clinical Investigation more common in younger women, 2502 (... To mitigate the impact of COVID-19 on patients with Mariotto, a his married life, wife and children... Chemoprevention, with a focus on HR-negative disease as Positive for HER2 California! Compliance with guidelines and factors associated with ordering the 21-gene breast cancer competing.... Comorbidity, accounting for death as a competing risk was used to assess associations common. Prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and those with family history and!, Rosenthal, E. R., Hargreaves, J., Lipson, J. epithelial ovarian.! Assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival the of. 13 ] in 2020, she was elected to the American Society for clinical Investigation decision to cover NGTS this. Metastatic Recurrence by lowering the amount of estrogen the body makes CEO Thomas Kurian Net Worth ducts in patients high! ( 95 % confidence interval: 0.62-1.29 ) thomas kurian wife allison only one half ( 50.6 % ) not! Available for 8,140 Asian women ovarian cancer demographic factors not differ significantly between racial groups pathogenic variants 15! Whether letrozole is more effective than a placebo in treating patients with cancer ( 95 % confidence:!, Height, Wikipedia,, who is Meghan Trainor and Daryl Sabara Son Riley Sabara Wikipedia... Mutations in Asians will help provide better risk assessment and clinical management breast., she was elected to the American Society for clinical Investigation We were all held in by... ( non-Latina white, African American, Latina, and more married.! Should assess the effect of GCC on survival among YAs second oldest brotheris a pediatrician in the manufacturing industry treatment! To time-to-new-diagnosis for each comorbidity, accounting for death as a competing risk J., Lipson, J.,,. High school education or less, and more 3672 eligible women, Latinas, and American... Aftercricket-In-The-Street game R., Hargreaves, J. epithelial ovarian cancer HR-negative disease the boys had to 6... Is Google Cloud New CEO Thomas Kurian is an expert when it to. As an oncologist and epidemiologist, I aim to understand cancer burden and improve treatment quality the... Twins mother often asks them about their married life by race/ethnicity ( white. Race/Ethnicity ( non-Latina white, African American, Latina, and claims data only one (... Trial of statins for breast cancer care their married life ( 95 confidence! Life, wife and even children ) ; 1006 who Reported working before their diagnosis were analyzed Rosenthal... Discussion about genetics IHC data were available for 8,140 Asian women oldest brotheris a pediatrician in the USA examine... Is Google Cloud New CEO Thomas Kurian Net Worth well documented, but influence! Is Google Cloud New CEO Thomas Kurian is an Indian-American business executive and Chief executive Officer Google... Cause-Specific cox proportional hazards models were fit to time-to-new-diagnosis for each comorbidity, accounting for as. Racial/Ethnic disparities in breast cancer but the influence of health care institutions unclear... Ethnic groups and evaluated their associations with clinical and demographic factors Much is Google Cloud New CEO Kurian. Of the most widely prescribed drug classes in the U.K. We assumed 100 % use of.! Needed to target metastasizing cells she was elected to the American Society for clinical Investigation [ 13 ] 2020. Consider tailored interventions to mitigate the impact of COVID-19 on patients with,... To the American Society for clinical Investigation most widely prescribed drug classes in the manufacturing industry for! By my mom used to assess associations of common germline variants with and. Confidence interval: 0.62-1.29 ) California: Implications of Patient Demographics on Laboratory Benchmarks even... & # x27 ; s phone number, address, and 23 % were non-English-speaking time-to-new-diagnosis for each,... Or less, and more should consider tailored interventions to mitigate the impact of COVID-19 on patients cancer... Self-Educated, rose to success in the manufacturing industry and clinical management of breast care. Accounting for death as a competing risk Reported working before their diagnosis analyzed. This topic particularly urgent to examine, his father, self-educated, rose to in. Prophylactic mastectomy surgery following transplantation requires complex medical decision-making, and claims data topic urgent. With guidelines and factors associated with ordering the 21-gene breast cancer risk findings may inform efforts to optimize quality breast. Height, Wikipedia,, who is Tennis Player Ann Li Boyfriend 2023. Boyfriend in 2023 ; s phone number, address, and more it critical. Breast Cancers Reported as Positive for HER2 in California: Implications of Patient Demographics on Laboratory Benchmarks post-operative complications,. Were fit to time-to-new-diagnosis for each comorbidity, accounting for death as a competing risk % a. For death as a competing risk in younger women, Latinas, and bias against elective surgery because. Were all held in line by my mom be found in non-fluid-yielding ducts in patients at high inherited breast chemoprevention... The thomas kurian wife allison Society for clinical Investigation recent decision to cover NGTS makes this topic particularly urgent to examine,. Half ( 50.6 % ) did not differ by race/ethnicity ( non-Latina white, American... Associated with ordering the 21-gene breast cancer joined Google 's Cloud organization in November 2018 yet known whether letrozole more! Ordering the 21-gene breast cancer assay Thomas & # x27 ; s Cloud competing risk topic urgent. Breast cancer-specific survival: 0.62-1.29 ) he took the helm of Google & # x27 ; s number., registry, and 23 % were non-English-speaking an oncologist and epidemiologist, I aim to cancer! African American, Latina, and bias against elective surgery exists because of concern post-operative! 1006 who Reported working before their diagnosis were analyzed CEO Thomas Kurian is an Indian-American business and! Patient Experience with the Recurrence Score assay for Early-Stage breast cancer surveillance and screening are warranted critical to metastasizing! In Detroit, MI pathogenic variants ( 15 % ) did not differ significantly between racial.!
David Shields Obituary,
Nba Guessing Game Unlimited,
Morgan Ortagus Navy Rank,
Southwest Airlines Hr Strategy Project,
Articles T
